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Clinicians 2017-12-05T17:33:45+00:00

How Our Technology Works

Aperiomics solves inadequate pathogen testing by combining deep next-generation sequencing (NGS) with its powerful Xplore∙NGS℠ software.  This combination of technologies allows virtually any biological sample to be tested for virtually any microorganism.

Solution Overview:

  1. Collect sample (swab, blood, tissue, urine, stool, plant, animal, etc.)
  2. Extract genetic information (DNA and/or RNA) from sample in CLIA/CAP laboratory
  3. Use NGS to generate raw sequence data from all microorganisms in sample
  4. QC and analyze raw sequence data using Xplore-NGS℠ to identify pathogens in sample
  5. Report all bacteria, DNA viruses, parasites and fungi identified along with the abundance of each

Superior, Cutting-Edge Technology

Aperiomics uses the latest technology from the best minds in genomics and microbial testing. Next-generation sequencing is performed using Illumina sequencers. Once a complete genetic fingerprint of the sample is created, the human portion is removed and the remaining microbial data is run through our proprietary software and against the Aperiomics Microbial Database™. It’s a comprehensive database of microorganisms, including the world’s largest collection of pathogens. This technology allows “all-in-one” testing from any sample and is only available through Aperiomics.

Getting Started

Set up free account

Order collection kits to have on hand

REQUEST KIT

Collect patient samples

Complete requisition form

Ship to Aperiomics at no cost

Receive & interpret report

Aperiomics has successfully found many infections missed by standard testing. By utilizing the Aperiomics Microbial Database, my interstitial cystitis patients have been able to finally identify not only bacteria, but fungal and viral infections contributing to their chronic bladder symptoms and then receive the appropriate treatment needed to cure what was previously thought to be a chronic, degenerative, and incurable condition.

Ruth Kriz, APRN

Aperiomics provides state of the art DNA testing for over 30,000 microbes of the viral, bacterial, parasitic and fungal variety.  This is a powerful silver bullet in testing for any savvy physician to diagnose the underlying root causes of most medical illness from chronic fatigue to headaches to IBS and a variety of pain syndromes, just to name a few. The staff are friendly, approachable and responsive. It has made a significant difference in the care of my patients and has saved many lives.

LH Zackrison, MD,

Clinician FAQs

Will you contact my doctor? 2017-10-23T13:31:03+00:00

We will not contact your doctor until you submit your sample to us for testing. If you would like us to contact your doctor before you order a collection kit, just let us know and we will reach out to them.

Who is Aperiomics? 2017-07-10T19:49:48+00:00

Aperiomics is a biotechnology company that saves lives.  Healthcare providers and patients call on us to identify infectious diseases that other tests have missed.  We are the only company of its kind and scope in the world.  Aperiomics can identify any known pathogen (bacteria, virus, fungi or parasite) in a single test through next-generation sequencing (NGS) of the DNA or RNA in a patient’s sample.  Then we compare the genetic fingerprint of that sample against the Aperiomics Microbial Database™, the most comprehensive database of microorganisms, including the world’s largest collection of pathogens. We then send a report of all identified pathogens and non-pathogens, including the abundance of each.  Our technology helps medical professionals solve difficult medical cases, remove guesswork and limit the use of antibiotics.

What does Aperiomics test for? 2017-07-10T19:50:06+00:00

Aperiomics tests for all known bacteria, virus, parasites and fungi.  This includes microbes that can cause intestinal issues, urinary tract infections, Lyme disease and many other issues.

Do I need to be sick in order to have Aperiomics test me? 2017-07-10T19:50:41+00:00

No, you do not need to be sick to be tested.  In some cases it may be desired to know one’s normal microbial population.  Aperiomics can perform a complete metagenomic microbiome assessment from any clinical sample.  You may use that as a baseline in case you do get sick for comparison.

Do I have to be a doctor to order your testing services? 2017-07-10T19:51:02+00:00

Aperiomics typically requires a clinician be involved in the collection and ordering of our testing.  This allows for the proper documentation for potential insurance reimbursement, as well as allowing for proper interpretation of results for the patient.

Does Aperiomics test for Lyme Disease? 2017-12-05T17:34:45+00:00

Yes.  All known forms of Lyme and tick-bourne diseases are in the Aperiomics Microbial Database.  Since Lyme Disease is very cryptic and likes to hide itself in various parts of the body, we recommend collection of blood, swab, urine and fecal samples to best chance of capturing the pathogen in the collection kits.  If the pathogens are not in a kit, we won’t be able to find it!

Why do I need to test multiple samples at one time? 2017-07-10T19:51:48+00:00

In some cases, if there is not a clear, single site of infection, we will request that multiple samples be collected and tested.  We cannot identify the microorganism(s) causing infection unless it is physically collected in the samples.  Thus, we will request multiple sample to ensure the best possible results.

Is there anything I need to be careful of when shipping my samples? 2017-07-10T19:52:40+00:00

When collected as instructed, samples are rendered non-infectious and stable at ambient temperatures for up to 30 days.  The supplies shipping materials will return your sample next-day, and thus no special concerns are needed when shipping your samples back to Aperiomics.

Do I need to discontinue any medications or treatment before testing? 2017-07-10T19:52:59+00:00

For us to get the best possible sample, it is typically recommended that all anti-infective treatments be stopped 3 days prior to sample collection.  This should be discussed with your healthcare provider.  All anti-infective treatments should be listed on your requisition form.

Do I need to refrigerate or freeze my biological samples? 2017-07-10T19:53:32+00:00

No.  Our specialized collection kits contain a solution that renders your samples non-infections and keeps the genetic material that we need intact for up to 30 days at room temperature.  Combined with our supplied packing materials, it also makes it safe for shipping… so no need to worry.

How do I know what type of sample(s) to have tested and what collection kits to order? 2017-07-10T19:53:53+00:00

Your physician should be able to tell you which kit or kits you’ll need to help identify the pathogens causing your illness.  While a single kit may be needed, in some instances patients may require additional kits (blood, swab, urine, fecal, tissue or semen) to capture the pathogens at the suspected source of the infection.  We won’t be able to give the best information if the microbes causing the issue aren’t collected in the kit!

How long does it take to get my test results? 2017-07-10T19:54:08+00:00

Testing typically takes 1-2 weeks.

How do I receive my results? 2017-07-10T19:54:20+00:00

Results are sent to your healthcare provider securely and directly.

How much does it cost? 2017-11-10T21:17:03+00:00

Our pricing ranges from $750 to 1000 per sample, depending on several factors.  Insurance companies may reimburse a portion of the price.  We accept Flexible Spending Accounts.  And we do our best to help make this technology accessible to anyone in need.

Is Aperiomics testing covered by insurance? 2017-07-10T19:55:05+00:00

Aperiomics’ services are self-pay.  We do not work directly with insurance companies.  However, we will supply CPT codes on your receipt for our services that you may submit to your insurance companies for potential reimbursement.  We are seeing partial to significant reimbursements at this time.

How does Aperiomics testing differ from what other companies offer? 2017-07-10T19:55:31+00:00

Most labs test for just one or a handful of pathogens at a time.  Aperiomics tests for ALL known pathogens at once!  This is the most comprehensive testing available in the world and your best option for identifying chronic or cryptic infections.

Why is next-generation sequencing testing more accurate than culture-growing testing? 2017-07-10T19:55:54+00:00

Culture is a 100+ year old technology that is limited to identifying only what will grow in culture.  Given that many microorganisms will not grow in culture, this technology is dramatically limited in the number of microorganisms that can be identified.  Culture creates bias because just one bacterial cell can grow and render a sample positive for that bacteria, irrespective of if that bacteria is causing an active infection.  Additionally, culture does not allow for consistent, objective identification of microorganisms to the species level.

NGS is more specific than culture can be because it identifies the identity of microorganisms according to the genetic sequence and not simply appearance of growth in culture.

What’s the difference between PCR and next-generation sequencing testing? 2017-07-10T19:56:09+00:00

PCR is a technology that makes many copies of a small portion of a microorganism’s genetic information.  It can be inexpensive and sensitive, but is extremely limited in how many microorganisms can be identified in a single test – typically less than a dozen in one test.  Further, because PCR creates many copies of small genetic pieces, it is heavily biased and cannot be used to assess abundance of microbial populations.

 

In contrast, NGS (whole genome shotgun sequencing) creates a genetic fingerprint of everything in the sample.  It is a much more comprehensive approach, capable of identifying tens of thousands of microorganisms in one sample, only limited by the availability of sequence data.  Aperiomics’ approach to NGS reduces as much bias as possible and allows abundance of microbial populations to be assessed.

What’s the difference between 16S and whole genome shotgun sequencing? 2017-07-10T19:56:18+00:00

16S sequencing is similar to PCR in that it creates many copies of specific genetic information.  These copies are then compared to a database to identify the bacteria present in a given sample.  16S sequencing is good at identifying thousands of bacteria to the genus level, but is unable to identify virus, fungi, or parasites.  Whole genome next-generation sequencing, on the other hand, is able to identify tens of thousands of microorganisms and differentiate species of bacteria, virus, parasites, and fungi.

What does Aperiomics have planned in the future? 2017-07-10T19:56:41+00:00

Items that are in the pipeline or in development now include drug resistance identification, the ability to identify true unknowns, disease prediction and biosurveillance.

LEARN MORE ABOUT HOW WE CAN HELP

The Aperiomics Microbial Database™ is a comprehensive microbial database of microorganisms, including the world’s largest collection of pathogens.

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