Technology & Accreditation
Proven Science. Results that Matter.
Aperiomics harnesses years of cutting-edge research—developed within George Washington University’s Computational Biology Institute and supported by the National Science Foundation—to bring you the new gold standard in microbial testing and bioinformatics.
The Aperiomics Difference
We use a technology called deep metagenomic sequencing to create a genetic fingerprint of every known microorganism in a given sample.
After we clean up the data we run the remaining sequences through Xplore-ID℠, our industry-leading metagenomic algorithm, and against Xplore-DB℠, one of the largest, most complete microbial databases.
Efficient and Cost-effective
Since our test allows for the identification of all known microorganisms—unlike older methods, which only test for a few microbes at a time—our cost per microbe is far more affordable than any other method.
of older testing fails to identify the causes of infection
of the genomic fingerprint is examined in Aperiomics testing
Aperiomics maintains a CLIA- certified laboratory. We also partner with the same laboratories routinely used by clinicians and hospitals. These are CLIA-certified labs, vetted by the state and federal government for precision, accuracy, and validity as well as independent third-party performance verifications. We only work with the best because we have the highest standards for our own work, too.
Who is Aperiomics?
Aperiomics is the only company of its kind and scope in the world. It is revolutionizing the way that medical professionals around the world detect and diagnose infections. Supported by the National Science Foundation, Aperiomics identifies every known bacteria, virus, fungus, and parasite through deep shotgun metagenomic sequencing. We help doctors and their patients identify the causes of infections that other tests cannot identify, thus streamlining the path to a positive clinical outcome. Many patients that we have helped were sick for years with no understanding of why. Patients and their physicians often contact Aperiomics after hearing about our life-changing success stories. The complete genetic fingerprint of a sample is created and compared to Aperiomics’ Xplore- PATHO database – a comprehensive database of over 37,000 microorganisms, including the world’s largest collection of known pathogens. Aperiomics was named Life Science’s Innovator of the Year in 2016 and International Start Up of the Year in 2018.
What does Aperiomics test for?
Aperiomics tests for all known bacteria, virus, parasites and fungi based on the sequenced genomes from thousands of scientists around the world. This includes microbes that can cause intestinal issues, urinary tract infections, Lyme disease and many other issues.
How does Aperiomics testing differ from what other companies offer?
Most labs test for just one or a handful of pathogens at a time. Others are only focuse on one aspect like bacteria. Aperiomics tests for ALL known pathogens at once! This is the most comprehensive testing available on the market and one of the best options for identifying chronic or cryptic infections.
What’s the difference between PCR and next-generation sequencing testing?
PCR is a technology that makes many copies of a small portion of a microorganism’s genetic information. It can be inexpensive and sensitive, but is extremely limited in how many microorganisms can be identified in a single test – typically less than a dozen in one test. Further, because PCR creates many copies of small genetic pieces, it is heavily biased and cannot be used to assess abundance of microbial populations.
In contrast, NGS (shotgun metagenomic sequencing) creates a genetic fingerprint of everything in the sample. It is a much more comprehensive approach, capable of identifying tens of thousands of microorganisms in one sample, only limited by the availability of sequence data. Aperiomics’ approach to NGS reduces as much bias as possible and allows abundance of microbial populations to be assessed.
Why is next-generation sequencing(shotgun metagenomics) testing more accurate than culture-growing testing?
Culture is a 100+ year old technology that is limited to identifying only what will grow in culture. Given that many microorganisms will not grow in culture, this technology is dramatically limited in the number of microorganisms that can be identified. Culture creates bias because just one bacterial cell can grow and render a sample positive for that bacteria, irrespective of if that bacteria is causing an active infection. Additionally, culture does not allow for consistent, objective identification of microorganisms to the species level.
Not all NGS techniques are the same though, there are multiple different forms. Some, used by our competitors only look at bacteria and have difficulty looking at the species and strain level. The type of NGS we use, called shotgun metagenomic sequencing, is one of the most powerful among NGS techniques able to do it all.
Shotgun metagenomics is more specific than culture can be because it identifies the identity of microorganisms according to the genetic sequence and not simply appearance of growth in culture.
What’s the difference between 16S NGS and shotgun metagenomics sequencing NGS?
16S NGS is similar to PCR in that it creates many copies of specific genetic information. These copies are then compared to a database to identify the bacteria present in a given sample. 16S sequencing is good at identifying thousands of bacteria to the genus level, but is unable to identify virus, fungi, or parasites. Deep shotgun metagenomics sequencing, on the other hand, is able to identify tens of thousands of microorganisms and differentiate species of bacteria, virus, parasites, and fungi.
Do patients or customers need to be sick in order to have Aperiomics test them?
No, patients or general customers do not need to be sick to be tested. In some cases it may be desired to know one’s normal microbial population. Aperiomics can perform a complete metagenomic microbiome assessment from any clinical sample.
Many patient’s have found it beneficial to know what their healthy body’s microbial state looks like to serve as a baseline for comparison in the event they do become ill in the future.
What does Aperiomics have planned in the future?
Items that are in the pipeline or in development now include drug resistance identification, the ability to identify true unknowns, disease prediction and biosurveillance.